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Platelet-activating factor receptor.

Zen-ichiro Honda·Satoshi Ishii·Takao Shimizu
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Abstract

Platelet-activating factor (PAF) is a pro-inflammatory lipid mediator possessing a unique 1-O-alkyl glycerophospholipid (GPC) backbone (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholin). Cloned PAF receptor, which belongs to the G protein-coupled receptor superfamily, transduces pleiotropic functions including cell motility, smooth muscle contraction, and synthesis and release of mediators and cytokines via multiple heterotrimeric G proteins. Pharmacological studies have suggested that PAF functions in a variety of settings including allergy, inflammation, neural functions, reproduction, and atherosclerosis. Establishment of PAFR(-/-) mice confirmed that the PAF receptor is responsible for pro-inflammatory responses, but that its roles in other settings remain to be clarified.

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Amino Acid SequenceAnimalsHumansMembrane ProteinsPlatelet Activating FactorPlatelet Membrane GlycoproteinsProtein ConformationReceptors, Cell SurfaceReceptors, G-Protein-CoupledSignal TransductionJournal ArticleReview

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Zen-ichiro Honda, Satoshi Ishii, Takao Shimizu. 2002. Platelet-activating factor receptor.. https://doi.org/10.1093/oxfordjournals.jbchem.a003164

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