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A prospective randomized study: day 2 versus day 5 embryo transfer.

Ingrid Van der Auwera·Sophie Debrock·Carl Spiessens·Hilde Afschrift·Els Bakelants·Christel Meuleman·Luc Meeuwis·Thomas M D'Hooghe
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Abstract

BACKGROUND: This randomized controlled study was performed in an unselected IVF/ICSI population to test the hypothesis that blastocyst transfers result in higher clinical pregnancy rates (CPR) per oocyte retrieval when compared with day 2 transfers. METHODS: Blind randomization for transfer on day 2 (group 1) or day 5/6 (group 2) was performed before stimulation. Oocytes and embryos were cultured in sequential media in 5.5% CO(2), 5% O(2), 89.5% N(2) and 90% humidity. A maximum of two embryos was transferred. RESULTS: The two groups were similar for age, IVF indication, number of treatment cycles, rate of ICSI/IVF, number of fertilized oocytes and number of embryos transferred. The CPR/oocyte retrieval was comparable in group 1 (32%) and in group 2 (44%), while the CPR/embryo transfer was significantly higher (P < 0.01) in group 2 (60%) than in group 1 (35%). Similarly, the implantation rate per embryo transferred was significantly higher (P < 0.03) in group 2 (46%) than in group 1 (29%). The cryo-augmented delivery rate/oocyte retrieval was comparable in group 2 (36.3%) and in group 1 (28.6%). CONCLUSION: This randomized study in an unselected population showed a significantly higher CPR/embryo transfer and a tendency toward a higher CPR/oocyte retrieval in patients receiving blastocysts when compared with day 2 transfers.

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AdultEmbryo TransferFemaleFertilization in VitroHumansPregnancyProspective StudiesSperm Injections, IntracytoplasmicTime FactorsClinical TrialComparative StudyJournal ArticleRandomized Controlled Trial

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BibTeXRIS

Ingrid Van der Auwera, Sophie Debrock, Carl Spiessens, Hilde Afschrift, Els Bakelants, Christel Meuleman, Luc Meeuwis, Thomas M D'Hooghe. 2002. A prospective randomized study: day 2 versus day 5 embryo transfer.. https://doi.org/10.1093/humrep%2F17.6.1507

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