Ras processing as a therapeutic target in hematologic malignancies.

Doan Thuy Le; Kevin M Shannon

doi:10.1097/00062752-200207000-00008

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Ras processing as a therapeutic target in hematologic malignancies.

Doan Thuy Le·Kevin M Shannon

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Abstract

Knowledge of signal transduction pathways has uncovered therapeutic targets for cancer. Based on genetic and biochemical studies of leukemia cells, inhibiting hyperactive Ras represents a rational therapeutic strategy for many hematologic malignancies. Because posttranslational processing by farnesyltransferase is essential for transformation by oncogenic Ras, specific inhibitors of this enzyme are being evaluated as cancer therapeutics. The authors review recent laboratory insights on farnesyltransferase biology and on the development of inhibitors, summarize preclinical and clinical data in myeloid malignancies, and briefly discuss other strategies of interfering with hyperactive Ras.

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Alkyl and Aryl Transferases Animals Clinical Trials as Topic Drug Evaluation, Preclinical Enzyme Inhibitors Farnesyltranstransferase Forecasting Hematologic Neoplasms Humans MAP Kinase Signaling System Signal Transduction ras Proteins Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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Doan Thuy Le, Kevin M Shannon. 2002. Ras processing as a therapeutic target in hematologic malignancies.. https://doi.org/10.1097/00062752-200207000-00008

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