Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection.

John Leander Z Po; Elizabeth M Gardner; Farvardin Anaraki; Peter D Katsikis; Donna M Murasko

doi:10.1016/s0047-6374(02)00010-6

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PubMed · 12044966

Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection.

John Leander Z Po·Elizabeth M Gardner·Farvardin Anaraki·Peter D Katsikis·Donna M Murasko

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Abstract

The mechanism of the age-associated decrease in CD8+ T cell response of mice to virus infection was examined in young adult (6 months) and aged (22 months) C57BL/6 mice during primary pulmonary influenza A virus infection. A significant age-associated decrease in both the percentage (P<0.0001) and number (P<0.05) of CD8+ T cells binding MHC Class I tetramers containing influenza A nucleoprotein (NP) epitope and in virus-specific CTL activity (P<0.05) was observed with pulmonary lymphocytes. The percentage of NP+CD8+ cells of individual mice strongly correlated with NP-specific cytotoxic activity (r(2)=0.77, P<0.02) and with the percentage of CD8+ cells that produced interferon-gamma (r(2)=0.86, P<0.002) in both young and aged mice. Comparable expression of the CD28, CD25, and the memory CD44(hi)/CD62L(lo) phenotype was detected on NP+CD8+ lymphocytes from mice of both age groups. There was a delay in the maximal expansion of NP+CD8+ cells in aged compared to young mice that paralleled a delay in maximal cytotoxic activity and in virus clearance. These data suggest that the age-related impairment of CD8+ lymphocyte activity during a primary influenza A infection is due to a defect in the expansion, rather than in effector activity, of influenza-specific CD8+ T cells.

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Aging Animals CD8-Positive T-Lymphocytes Disease Models, Animal Epitopes, T-Lymphocyte Humans Immunophenotyping Influenza A virus Influenza, Human Interferon-gamma Lung Mice Mice, Inbred C57BL Nucleocapsid Proteins Nucleoproteins RNA-Binding Proteins Viral Core Proteins Journal Article Research Support, U.S. Gov't, P.H.S.

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John Leander Z Po, Elizabeth M Gardner, Farvardin Anaraki, Peter D Katsikis, Donna M Murasko. 2002-04-30. Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infection.. https://doi.org/10.1016/s0047-6374(02)00010-6

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