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New synthetic catecholate-type siderophores with triamine backbone.

Lothar Heinisch·Peter Gebhardt·Renate Heidersbach·Rolf Reissbrodt·Ute Möllmann
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Abstract

New analogues of triscatecholate siderophores based on linear or tripodal triamines with or without spacer groups or lipophilic and hydrophilic substituents were synthesized. The catecholate moieties were prepared in OH-forms, as acetylated compounds or masked as 8-methoxycarbonyloxy-2,4-dioxo-1,3-benzoxazine derivatives. Some of the new compounds were active as siderophores tested by growth promotion assays using various gram-negative bacteria and mycobacteria under iron limitation and by CAS-assay. Structure-activity-correlations have been studied.

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AminesCatecholsCell DivisionMolecular StructureMorganella morganiiPseudomonas aeruginosaSiderophoresJournal Article

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Lothar Heinisch, Peter Gebhardt, Renate Heidersbach, Rolf Reissbrodt, Ute Möllmann. 2002. New synthetic catecholate-type siderophores with triamine backbone.. https://doi.org/10.1023/a%3A1015293900133

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