Anticestode quinolinehydrazones.

C Pellerano; L Savini; C E Berkoff; J Thomas; P Actor

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PubMed · 1204834

Anticestode quinolinehydrazones.

C Pellerano·L Savini·C E Berkoff·J Thomas·P Actor

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Abstract

One hundred and seven 4-quinolinehydrazones were synthesized and tested in vivo against the tapeworm Hymenolepis nana. Twenty-five derivatives showed significant cestocidal activity; structure-activity correlations were performed using Free-Wilson methodology. Two compounds, 2,6-dimethyl-4-[(3-pyridinylmethylene)hydrazino]quinoline and 2,6-dimethyl-4-[2p][(6-methyl)pyridinylmethylene]hydrazino)quinoline, predicted to be maximally active, effected 100% reduction of H. nana in mice at 200 mg/kg, p.o.

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Animals Anticestodal Agents Hydrazones Hymenolepiasis Hymenolepis Male Mice Quinolines Structure-Activity Relationship Journal Article

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C Pellerano, L Savini, C E Berkoff, J Thomas, P Actor. 1975. Anticestode quinolinehydrazones.. https://pubmed.ncbi.nlm.nih.gov/1204834/

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