[Persistent polyclonal B-cell lymphocytosis].

Troussard; H Mossafa; G Flandrin

PubMed · 12050042

[Persistent polyclonal B-cell lymphocytosis].

Abstract

Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare and recently described entity. PPBL is diagnosed predominantly but not exclusively in women, usually smokers and is characterized by a moderate, chronic and absolute lymphocytosis (> 4 x 109/L). Peripheral blood examination show in all cases atypical binucleated lymphocytes. A polyclonal serum IgM is also associated and HLA-DR7 expression is present in most cases. The B cells are polyclonal with kappa and lambda light-chain expression. No clonal rearrangement of immunoglobulin heavy chain genes is observed. Finally, +i(3q) is a recurrent chromosomal abnormality and detected in 77% of cases with premature chromosome condensation in 50% and both abnormalities in 41% of cases. The benign clinical course of PPBL and lack of biological evolution in the majority of cases suggest that recognition is so important that aggressive therapy could be avoided.

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B-Lymphocytes Female Gene Rearrangement, B-Lymphocyte Genes, Immunoglobulin Humans Immunoglobulin kappa-Chains Immunoglobulin lambda-Chains Lymphocytosis Male Sex Characteristics English Abstract Journal Article Review

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Troussard, H Mossafa, G Flandrin. [Persistent polyclonal B-cell lymphocytosis].. https://pubmed.ncbi.nlm.nih.gov/12050042/

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