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PubMed · 12054069

Memory T-cells in non-lymphoid tissues.

Linda S Cauley·Robert J Hogan·David L Woodland
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Abstract

Recent studies have shown that long-lived memory CD8 T-cell populations can be subdivided into two distinct groups. The central pool of resting memory cells in lymph organs has been extensively analyzed. However, a second subset of partially activated CD8 memory T-cells has recently been identified in non-lymphoid tissues. In respiratory virus models, a strong correlation between the numbers of antigen-specific T-cells in lung tissues and effective protective cellular immunity suggests that boosting the numbers of memory T-cells in non-lymphoid tissues may be a fruitful approach in vaccine development for viral infections.

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AnimalsCD8-Positive T-LymphocytesHumansImmunologic MemoryLungRespiratory Tract InfectionsRespirovirus InfectionsSendai virusT-LymphocytesJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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Linda S Cauley, Robert J Hogan, David L Woodland. 2002. Memory T-cells in non-lymphoid tissues.. https://pubmed.ncbi.nlm.nih.gov/12054069/

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