Approaching exponential growth with a self-replicating peptide.

Roy Issac; Jean Chmielewski

doi:10.1021/ja026024i

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Approaching exponential growth with a self-replicating peptide.

Roy Issac·Jean Chmielewski

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Abstract

Self-replicating peptide systems hold great promise for a wide range of technological applications, as well as to address fundamental questions pertaining to the molecular origins of life. The development of self-replicating compounds capable of high efficiency, however, has remained elusive. Here we disclose a successful strategy whereby modulation of coiled-coil stability results in remarkable catalytic efficiency for self-replication. By shortening the peptide to the minimum length necessary for coiled-coil formation a highly efficient self-replicating system was obtained due to very low background reaction rates, bringing the efficiency close to naturally occurring enzymes.

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Amino Acid Sequence Hydrogen-Ion Concentration Molecular Sequence Data Peptides Protein Denaturation Protein Structure, Secondary Structure-Activity Relationship Templates, Genetic Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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Roy Issac, Jean Chmielewski. 2002-06-19. Approaching exponential growth with a self-replicating peptide.. https://doi.org/10.1021/ja026024i

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