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PubMed · 12062500

Non-linear mixed effects models for the evaluation of dissolution profiles.

E Adams·D Coomans·J Smeyers-Verbeke·D L Massart
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Abstract

The use of non-linear mixed effects models to describe dissolution data has been evaluated. A theoretical part is included to introduce this approach to scientists who are not familiar with this type of statistics. The standard settings of the statistical software package (S-plus) are used as much as possible. Several mathematical functions like the Weibull, logistic, first-order and Gompertz are employed as basis for the non-linear mixed effects models. Examples are given using dissolution data of immediate and extended release tablets. The results are compared with those obtained using linear mixed effects models.

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Linear ModelsModels, StatisticalSoftwareSolubilityTabletsJournal ArticleResearch Support, Non-U.S. Gov't

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E Adams, D Coomans, J Smeyers-Verbeke, D L Massart. 2002-06-20. Non-linear mixed effects models for the evaluation of dissolution profiles.. https://doi.org/10.1016/s0378-5173(02)00127-8

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