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PubMed · 12076534

Membrane proteins: shaping up.

Chen-Ni Chin·Gunnar von Heijne·Jan-Willem L de Gier
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Abstract

Over recent years, much progress has been made in the identification and characterization of factors involved in the biosynthesis of integral membrane proteins of the helix-bundle type. In addition, our knowledge of membrane protein structure and the forces stabilizing helix-helix interactions in a lipid environment is expanding rapidly. However, it is still not clear how a membrane protein folds into its final form in vivo, nor what constraints there are on the folded structure that results from the mechanistic details of translocon-mediated assembly rather than simply from the thermodynamics of protein-lipid interactions.

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Bacterial ProteinsCell MembraneMembrane ProteinsModels, MolecularProtein FoldingProtein Structure, SecondaryProtein Structure, TertiaryProtein TransportJournal ArticleResearch Support, Non-U.S. Gov't

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Chen-Ni Chin, Gunnar von Heijne, Jan-Willem L de Gier. 2002. Membrane proteins: shaping up.. https://doi.org/10.1016/s0968-0004(02)02082-0

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