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Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection.

Tina Deignan·Michael P Curry·Derek G Doherty·Lucy Golden-Mason·Yuri Volkov·Suzanne Norris·Niamh Nolan·Oscar Traynor·Gerry McEntee·John E Hegarty·Cliona O'Farrelly
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Abstract

BACKGROUND/AIMS: The intrahepatic immune system is likely to play a key role in determining the outcome of hepatitis C virus (HCV) infection. The hepatic lymphocyte repertoire is characterised by high CD8/CD4 T cell ratios and large numbers of gamma delta T cells, natural killer (NK) cells, NK T cells and NK receptor-positive T cells. It is not known which of these populations contribute to immunity against HCV or immune pathology. METHODS: To explore the relative contributions of lymphocyte subpopulations, we have compared the intrahepatic lymphocyte repertoires and cytokine expression in 13 patients with mild chronic hepatitis C infection, 14 with end-stage hepatitis C cirrhosis and five histologically normal livers by flow cytometry and immunohistochemistry. RESULTS: CD4(+) T cells bearing alpha beta T cell receptors (TCR) were significantly expanded in livers with chronic HCV infection while CD56(+) alpha beta T cells and V alpha 24 TCR-positive T cells were significantly depleted. Expanded CD4(+)T cells were predominantly Th1 cells, producing interferon-gamma but not interleukin-4. CONCLUSIONS: Failure to resolve HCV infection may be due to deficient innate and/or memory immune responses, while Th1 cells may mediate immune pathology.

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AdultAgedCD56 AntigenCD8-Positive T-LymphocytesFemaleFlow CytometryHepatitis C, ChronicHumansKiller Cells, NaturalLiverMaleMiddle AgedReceptors, Antigen, T-Cell, alpha-betaTh1 CellsJournal ArticleResearch Support, Non-U.S. Gov't

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Tina Deignan, Michael P Curry, Derek G Doherty, Lucy Golden-Mason, Yuri Volkov, Suzanne Norris, Niamh Nolan, Oscar Traynor, Gerry McEntee, John E Hegarty, Cliona O'Farrelly. 2002. Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection.. https://doi.org/10.1016/s0168-8278(02)00072-7

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