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PubMed · 12079752

RIM1: an edge for presynaptic plasticity.

György Lonart
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Abstract

Pioneering work suggests that a synaptic active zone protein, RIM1, regulates both short- and long-term glutamatergic presynaptic plasticity at certain synapses. In short-term plasticity, RIM1 accelerates the priming of synaptic vesicles for fusion; by contrast, in long-term potentiation of mossy fiber synapses in the hippocampal CA3 region, phosphorylated RIM1 acts through an unknown molecular pathway to enhance release of the excitatory neurotransmitter glutamate.

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AnimalsExocytosisGTP-Binding ProteinsHumansLong-Term PotentiationMossy Fibers, HippocampalNerve Tissue ProteinsSynaptic MembranesSynaptic TransmissionSynaptic VesiclesJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

György Lonart. 2002. RIM1: an edge for presynaptic plasticity.. https://doi.org/10.1016/s0166-2236(02)02193-8

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