[SV40 and cell immortalization].

H Q Xie; Z M Yang; Y Qu

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PubMed · 12080857

[SV40 and cell immortalization].

H Q Xie·Z M Yang·Y Qu

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Abstract

OBJECTIVE: To explore the SV40-mediated immortalization, the related factors and their roles in cell immortalization. METHODS: The original articles about cell immortalization and replicative senescence in recent decade were reviewed. RESULTS: Cell immortalization was a multifaceted phenomenon, it was involved in viral DNA integration, activation of telomerase, inactivation of growth suppressors, and so on, and their roles were closely related. CONCLUSION: The research on cell immortalization may be expected to provide important insights into a broad range of cellular biological phenomenon, and the immortalized cells can play important roles in the research of cell engineering and tissue engineering as standard cells.

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Animals Cell Transformation, Viral Cellular Senescence Epithelial Cells Fibroblasts Humans Muscle, Smooth, Vascular Simian virus 40 Journal Article Research Support, Non-U.S. Gov't Review

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H Q Xie, Z M Yang, Y Qu. 2000. [SV40 and cell immortalization].. https://pubmed.ncbi.nlm.nih.gov/12080857/

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