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NMR difference probe: a dual-coil probe for NMR difference spectroscopy.

Megan A Macnaughtan·Ting Hou·Ernesto MacNamara·Robert E Santini·Daniel Raftery
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Abstract

A unique probe designed to acquire nuclear magnetic resonance difference spectra of two samples is presented. The NMR Difference Probe contains two sample coils in a resonant circuit that switches between parallel excitation and serial acquisition to cancel common signals such as solvent peaks and impurities. Two samples containing a common analyte, acetonitrile, were used to demonstrate signal cancellation in a difference spectrum collected with a single pulse experiment. The cancellation was over 96% effective. The approach described has applications in the areas of solvent subtraction and spectral simplification.

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Magnetic Resonance SpectroscopySignal Processing, Computer-AssistedJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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Megan A Macnaughtan, Ting Hou, Ernesto MacNamara, Robert E Santini, Daniel Raftery. 2002. NMR difference probe: a dual-coil probe for NMR difference spectroscopy.. https://doi.org/10.1006/jmre.2002.2535

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