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BeadArray technology: enabling an accurate, cost-effective approach to high-throughput genotyping.

Arnold Oliphant·David L Barker·John R Stuelpnagel·Mark S Chee
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Abstract

The Human Genome Project has opened the door to personalized medicine, provided that human genetic diversity can be analyzed in a high-throughput and cost-effective way Illumina has developed a genotyping system that combines very high throughput and accuracy with low cost per SNP analysis. The system uses our BeadArray platform, a high level of multiplexing, and modular, scalable automation to meet the requirements for cost-effective, genome-wide linkage disequilibrium studies. As implemented in a high-throughput genotyping service facility at Illumina, the system has a current capacity of one million SNP assays per day and is easily expandable. Each SNP call is associated with a quality score that correlates with accuracy

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Cost-Benefit AnalysisDNA Mutational AnalysisEquipment DesignFiber Optic TechnologyGenome, HumanGenotypeHumansInformation Storage and RetrievalMiniaturizationOligonucleotide Array Sequence AnalysisPolymorphism, Single NucleotideReproducibility of ResultsSensitivity and SpecificitySequence Analysis, DNAUnited StatesJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Arnold Oliphant, David L Barker, John R Stuelpnagel, Mark S Chee. 2002. BeadArray technology: enabling an accurate, cost-effective approach to high-throughput genotyping.. https://pubmed.ncbi.nlm.nih.gov/12083399/

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