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Thymic development and repertoire selection: the rat perspective.

T Hünig·N Torres-Nagel·B Mehling·H J Park·T Herrmann
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Abstract

This review summarizes our current knowledge of T-cell maturation and repertoire selection in the rat thymus. Some unique features of early thymocyte development and of CD4/CD8 lineage decision are described. A detailed analysis of lineage progression through the CD4, CD8 "double positive" compartment and T-cell receptor-induced CD8 T-cell maturation in cell culture is provided. A second emphasis is placed on interactions between germline-encoded T-cell receptor elements with MHC molecules in thymic repertoire selection and alloreactivity

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AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationHumansMajor Histocompatibility ComplexRatsReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaReceptors, Interleukin-2Thymus GlandJournal ArticleResearch Support, Non-U.S. Gov'tReview

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T Hünig, N Torres-Nagel, B Mehling, H J Park, T Herrmann. 2001. Thymic development and repertoire selection: the rat perspective.. https://doi.org/10.1034/j.1600-065x.2001.1840102.x

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