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PubMed · 12090738

MitoExtra SuperGen.

Konstantina Grosios
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Abstract

SuperGen Inc is developing a cyclodextrin-based reformulation of mitomycin C (MitoExtra) for the potential treatment of gastic, pancreatic, breast lung and colorectal cancers. In April 2002, the NDA was pending approval from the US FDA after a March 2002 filing of a final response including data from a phase II trial [447618]. MitoExtra is a proprietary reformulation of the approved anticancer drug mitomycin C. SuperGen's reformulation is based on technology designed to improve the handling characteristics and safety profile of mitomycin C and other anticancer drugs by enhancing the drug's stability in solution form and 'shielding' it at the injection site [205482]. In a phase II study in patients with advanced solid tumors, MitoExtra showed no evidence of diminished efficacy or unexpected toxicity [447618]. In April 2000, SuperGen' was issued US-06048845, protecting the company's proprietary Extra technology platform [363494].

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2-Hydroxypropyl-beta-cyclodextrinAntineoplastic AgentsChemistry, PharmaceuticalClinical Trials as TopicCyclodextrinsExcipientsHumansInjections, IntravenousMitomycinStructure-Activity Relationshipbeta-CyclodextrinsJournal Article

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Konstantina Grosios. 2002. MitoExtra SuperGen.. https://pubmed.ncbi.nlm.nih.gov/12090738/

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