Association between intercellular adhesion molecule-1 E/K gene polymorphism and probable vascular dementia in humans.

Roberto Pola; Andrea Flex; Eleonora Gaetani; Pierangelo Papaleo; Demetrio De Martini; Laura Gerardino; Michele Serricchio; Paolo Pola; Roberto Bernabei

doi:10.1016/s0304-3940(02)00337-3

PubMed · 12095649

Association between intercellular adhesion molecule-1 E/K gene polymorphism and probable vascular dementia in humans.

Roberto Pola·Andrea Flex·Eleonora Gaetani·Pierangelo Papaleo·Demetrio De Martini·Laura Gerardino·Michele Serricchio·Paolo Pola·Roberto Bernabei

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Abstract

Intercellular adhesion molecule-1 (ICAM-1) is implicated in the pathogenesis of ischemic cardiovascular disorders, including cerebral ischemia. A common polymorphism of the ICAM-1 gene (K469E) has been recently reported. In this case-control study, we evaluated the association between this polymorphism and vascular dementia (VD) by studying 107 patients affected by probable VD and 115 age- and sex-matched controls. The frequency of the EE genotype was significantly higher in VD patients than controls (P=0.009). Logistic regression analysis indicated that the presence of the EE genotype significantly increased the risk of VD (odds ratio 3.25, P=0.024). Our findings support the hypothesis that ICAM-1 plays a role in the physiopathology of ischemic cerebrovascular disorders and suggest that genetic polymorphisms of ICAM-1 might be clinically important in the development and progression of neurodegenerative diseases.

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Aged Case-Control Studies Dementia, Vascular Female Genetic Predisposition to Disease Genotype Humans Intercellular Adhesion Molecule-1 Male Polymerase Chain Reaction Polymorphism, Genetic Risk Factors Journal Article

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Roberto Pola, Andrea Flex, Eleonora Gaetani, Pierangelo Papaleo, Demetrio De Martini, Laura Gerardino, Michele Serricchio, Paolo Pola, Roberto Bernabei. 2002-07-05. Association between intercellular adhesion molecule-1 E/K gene polymorphism and probable vascular dementia in humans.. https://doi.org/10.1016/s0304-3940(02)00337-3

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