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Structural-functional relationship of pathogen-associated molecular patterns: lessons from BCG cell wall skeleton and mycoplasma lipoprotein M161Ag.

Tsukasa Seya·Misako Matsumoto·Shoutaro Tsuji·Nasim A Begum·Ichiro Azuma·Kumao Toyoshima
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Abstract

The innate immune system senses microbial components by signaling receptors and induces phagocytosis by uptake receptors. The Toll-like receptor represents the signaling receptors that cause maturation of dendritic cells, while phagocytosis is supported by other receptor families. We identify the structural signatures of microbial components recognized by these receptors to establish the two-receptor hypothesis in innate immunity.

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Adjuvants, ImmunologicAnimalsAntigens, BacterialCell WallDendritic CellsDrosophila ProteinsImmunity, InnateLipoproteinsMacrophagesMembrane GlycoproteinsMycobacterium bovisMycoplasmaReceptors, Cell SurfaceStructure-Activity RelationshipToll-Like ReceptorsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Tsukasa Seya, Misako Matsumoto, Shoutaro Tsuji, Nasim A Begum, Ichiro Azuma, Kumao Toyoshima. 2002. Structural-functional relationship of pathogen-associated molecular patterns: lessons from BCG cell wall skeleton and mycoplasma lipoprotein M161Ag.. https://doi.org/10.1016/s1286-4579(02)01610-6

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