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Decrease of energy expenditure causes weight increase in olanzapine treatment - a case study.

M Virkkunen·K Wahlbeck·A Rissanen·H Naukkarinen·A Franssila-Kallunki
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Abstract

The aim of this study was to evaluate the mechanisms underlying weight gain induced by the atypical antipsychotic, olanzapine. We performed euglycemic, hyperinsulinemic clamp combined with indirect calorimetry on a 48-year-old male with antisocial personality disorder, alcohol dependence and paranoid ideation before and after one month of olanzapine (10 - 15 mg/day) therapy. The patient gave his informed, written consent for this study. The results were a weight gain of 6 kg and a decrease in both basal (from 1673 to 1613 kcal/24 h) and 3-hour (from 22.8 to 20.2 cal/kg fat free mass/min) energy expenditure. Serum thyroid hormone and high-density lipoprotein cholesterol levels decreased, and the triglyceride and low-density lipoprotein cholesterol levels increased. Insulin sensitivity did not change. We conclude that decreased basal energy expenditure may contribute to weight gain in olanzapine treatment.

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Antipsychotic AgentsBenzodiazepinesCalorimetry, IndirectEnergy MetabolismHumansMaleMiddle AgedOlanzapinePirenzepinePsychotic DisordersWeight GainCase ReportsJournal Article

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M Virkkunen, K Wahlbeck, A Rissanen, H Naukkarinen, A Franssila-Kallunki. 2002. Decrease of energy expenditure causes weight increase in olanzapine treatment - a case study.. https://doi.org/10.1055/s-2002-31521

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