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PubMed · 12108003

[Giant cell arteritis].

Abstract

Giant cell arteritis (GCA) or temporal arteritis is the most frequent systemic vasculitis in our area, and its incidence may be on the increase in the last years. GCA involves large and medium-sized vessels, with preference to the extracranial arteries, and it affects persons older than 50 years. The aetiopathogenesis is unknown, although several infectious agents may be implicated. A normal temporal artery biopsy do not exclude a GCA since the lesions may be skip. The most feared complications of GCA are permanent visual loss, ischemic strokes and thoracic and abdominal aortic aneurysms. The treatment consists of high-dose corticoids, and nowadays there is no effective therapeutic alternative without important adverse effects. The mortality of treated patients with GCA does not seem to be increased, probably due to a correct diagnosis and management of this entity.

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BibTeXRIS

J M Calvo Romero. 2002. [Giant cell arteritis].. https://pubmed.ncbi.nlm.nih.gov/12108003/

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Bayard Horton's clinicopathological description of giant cell (temporal) arteritis.

The author set out to review the thought processes of Bayard Horton as he was clinicopathologically describing the first cases of temporal arteritis. The Mayo Clinic records of the original temporal arteritis patients were examined. Horton obtained the first biopsies of the temporal arteries in temporal arteritis and was the first to describe the histopathology. Horton initially thought his first two patients had actinomycosis of the temporal arteries, but later abandoned this diagnosis. He reported these two patients in 1932 as 'an undescribed form of arteritis of the temporal vessels'. He was the first to describe jaw claudication. He saw a patient with blindness and symptoms suggestive of temporal arteritis before this complication was described in the literature, but initially felt the patient had some other disease. The sedimentation rate was elevated in his first patient. He cared for the first temporal arteritis patient ever treated with cortisone.

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