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MeCP2 and other methyl-CpG binding proteins.

Helle Faerk Jørgensen·Adrian Bird
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Abstract

DNA methylation is an epigenetic modification that is implicated in transcriptional silencing. Recently, it has become increasingly clear that both correct levels and proper interpretation of methylation are important factors for normal development and function of the human organism. One example is the neurological disorder Rett syndrome (RTT), which affects approximately one in 10,000 girls. RTT is caused by mutations in MeCP2, a protein that was identified by its ability to bind specifically to CpG-methylated DNA. Furthermore, MeCP2 represses transcription in a methylation-dependent manner, and it is the founding member of the family of methyl-CpG binding domain (MBD) proteins.

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AnimalsChromosomal Proteins, Non-HistoneCpG IslandsDNA MethylationDNA-Binding ProteinsDisease Models, AnimalFemaleHumansMethyl-CpG-Binding Protein 2MiceRepressor ProteinsRett SyndromeJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Helle Faerk Jørgensen, Adrian Bird. 2002. MeCP2 and other methyl-CpG binding proteins.. https://doi.org/10.1002/mrdd.10021

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