rRNA modifications and ribosome function.

Wayne A Decatur; Maurille J Fournier

doi:10.1016/s0968-0004(02)02109-6

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rRNA modifications and ribosome function.

Wayne A Decatur·Maurille J Fournier

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Abstract

The development of three-dimensional maps of the modified nucleotides in the ribosomes of Escherichia coli and yeast has revealed that most (approximately 95% in E. coli and 60% in yeast) occur in functionally important regions. These include the peptidyl transferase centre, the A, P and E sites of tRNA- and mRNA binding, the polypeptide exit tunnel, and sites of subunit-subunit interaction. The correlations suggest that many ribosome functions benefit from nucleotide modification.

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Binding Sites Escherichia coli Humans Models, Molecular Molecular Structure Nucleic Acid Conformation RNA, Bacterial RNA, Fungal RNA, Ribosomal Ribosomes Saccharomyces cerevisiae Journal Article Research Support, U.S. Gov't, P.H.S.

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Wayne A Decatur, Maurille J Fournier. 2002. rRNA modifications and ribosome function.. https://doi.org/10.1016/s0968-0004(02)02109-6

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