A colon tumor model for anticancer agent evaluation.

D P Griswold; T H Corbett

doi:10.1002/1097-0142(197512)36:6<2441::aid-cncr2820360627>3.0.co;2-p

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A colon tumor model for anticancer agent evaluation.

D P Griswold·T H Corbett

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Abstract

Colon tumors of mice were induced with 1, 2-dimethylhydrazine, N-nitroso-N-methylurethane, methylnitrosourea, and 4-methyl-N'-nitro-N-nitrosoguanidine. Of 82 transplantation attempts, four were successful, and the four tumors have been maintained as distinct tumor lines by subcutaneous transplantation. The tumors graded from II, adenocarcinoma, to IV, undifferentiated carcinoma. Volume-doubling times varied over a three-fold range, and metastatic potential ranged from 5 to about 100%. The tumors responded to treatment with some of the same agents found to be active in man. These included cyclophosphamide, 5-fluorouracil, and certain nitrosoureas. Preliminary evidence suggests that these tumor lines may be useful as experimental models.

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Animals Antineoplastic Agents Colonic Neoplasms Dimethylhydrazines Disease Models, Animal Methylnitronitrosoguanidine Methylnitrosourea Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred DBA Neoplasm Transplantation Neoplasms, Experimental Nitrosomethylurethane Transplantation, Homologous Journal Article Research Support, U.S. Gov't, P.H.S.

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D P Griswold, T H Corbett. 1975. A colon tumor model for anticancer agent evaluation.. https://doi.org/10.1002/1097-0142(197512)36%3A6%3C2441%3A%3Aaid-cncr2820360627%3E3.0.co%3B2-p

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