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PubMed · 12127460

Trends in protein evolution inferred from sequence and structure analysis.

L Aravind·Raja Mazumder·Sona Vasudevan·Eugene V Koonin
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Abstract

Complementary developments in comparative genomics, protein structure determination and in-depth comparison of protein sequences and structures have provided a better understanding of the prevailing trends in the emergence and diversification of protein domains. The investigation of deep relationships among different classes of proteins involved in key cellular functions, such as nucleic acid polymerases and other nucleotide-dependent enzymes, indicates that a substantial set of diverse protein domains evolved within the primordial, ribozyme-dominated RNA world.

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Evolution, MolecularPhylogenyProtein FoldingProtein Structure, TertiaryProteinsRNASequence Analysis, ProteinJournal ArticleReview

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L Aravind, Raja Mazumder, Sona Vasudevan, Eugene V Koonin. 2002. Trends in protein evolution inferred from sequence and structure analysis.. https://doi.org/10.1016/s0959-440x(02)00334-2

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