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An 'oligarchy' rules neural development.

David H Rowitch·Q Richard Lu·Nicoletta Kessaris·William D Richardson
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Abstract

Recent reports show that Olig genes, which encode the basic helix-loop-helix Olig transcription factors, are essential for development of oligodendrocytes. Surprisingly, Olig function is also required for formation of somatic motor neurons. These findings alter our views of how the oligodendrocyte lineage is generated and raise further questions about the underlying developmental relationships between neurons and glia.

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AnimalsBasic Helix-Loop-Helix ProteinsCell DifferentiationCell LineageCentral Nervous SystemDNA-Binding ProteinsGene Expression Regulation, DevelopmentalHumansMiceMice, KnockoutMotor NeuronsNerve Tissue ProteinsOligodendrocyte Transcription Factor 2OligodendrogliaStem CellsTranscription FactorsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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David H Rowitch, Q Richard Lu, Nicoletta Kessaris, William D Richardson. 2002. An 'oligarchy' rules neural development.. https://doi.org/10.1016/s0166-2236(02)02201-4

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