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Tissue factor pathway inhibitor can interact with platelets.

Takuya Nishioka·Masaharu Yokota·Masayuki Hino·Izumi Tsuda·Noriyuki Tatsumi
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Abstract

Tissue factor pathway inhibitor (TFPI) regulates the extrinsic pathway of blood coagulation. However, there is no report on interaction between TFPI and platelets other than that by Tsuji, who found that whole blood anticoagulated with TFPI exhibited remarkable decrease in platelet count. Our study revealed that washed platelets suspended in modified Tyrode's buffer (8 mM CaCl2) containing TFPI exhibit platelet aggregation. However, platelets aggregation was observed without TFPI, but its increase and intensity were slow and weak, compared to that in the presence of TFPI. This aggregation was inhibited by anti-CD41 (anti-GPIIb) antibody. This finding suggested that TFPI promotes platelet aggregation.

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Antibodies, MonoclonalBlood PlateletsHumansKineticsLipoproteinsPlatelet AggregationPlatelet Glycoprotein GPIIb-IIIa ComplexJournal Article

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BibTeXRIS

Takuya Nishioka, Masaharu Yokota, Masayuki Hino, Izumi Tsuda, Noriyuki Tatsumi. 2002-08-01. Tissue factor pathway inhibitor can interact with platelets.. https://doi.org/10.1016/s0022-1759(02)00145-x

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