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PubMed · 12135581

Multidrug resistance: can different keys open the same lock?

Parjit Kaur
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Abstract

Multidrug resistance (MDR), resulting from the energy-dependent efflux of structurally unrelated lipophilic compounds, is a major clinical problem. An important question concerns the number and nature of the drug-binding sites in the MDR proteins. A recent report on the high-resolution structure of QacR, a protein that regulates expression of an MDR protein, shows the presence of several independent, but linked binding sites within a single multifaceted drug-binding pocket. This report, for the first time, provides a basis for the specific binding of multiple drugs to a single protein. The significance of these findings and their relevance to the field of drug resistance is discussed.

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ATP Binding Cassette Transporter, Subfamily BAnimalsBinding SitesDrug Resistance, MultipleHumansPharmaceutical PreparationsJournal ArticleReview

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BibTeXRIS

Parjit Kaur. 2002. Multidrug resistance: can different keys open the same lock?. https://doi.org/10.1016/s1368-7646(02)00020-1

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