Developmental language disorder associated with polymicrogyria.

M M Guerreiro; S R V Hage; C A Guimarães; D V Abramides; W Fernandes; P S Pacheco; A M S G Piovesana; M A Montenegro; F Cendes

doi:10.1212/wnl.59.2.245

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Developmental language disorder associated with polymicrogyria.

M M Guerreiro·S R V Hage·C A Guimarães·D V Abramides·W Fernandes·P S Pacheco·A M S G Piovesana·M A Montenegro·F Cendes

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Abstract

BACKGROUND: Subtle disorders of neuronal migration occur in the brains of some dyslexic patients who presented developmental language disorder (DLD) during early childhood. OBJECTIVE: To investigate a possible neuroanatomical substrate based on neuroimaging evaluation in children with DLD. METHODS: The authors obtained psychological assessment, language evaluation, neurologic examination, and neuroimaging investigation. Inclusion criteria were as follows: children should be at least 4 years of age; primary complaint of language delay; normal hearing; IQ >70; and an informed consent form signed by parents or guardians. Exclusion criteria were severe motor and cognitive handicap. RESULTS: Fifteen children met all inclusion criteria. Ages ranged from 4 to 14 years and 11 were boys. Six patients presented diffuse polymicrogyria (PMG) around the entire extent of the sylvian fissure on MRI, and they had severe clinical manifestation of DLD: they did not speak at all or had mixed phonologic-syntactic deficit syndrome. Six children presented PMG restricted to the posterior aspects of the parietal regions, and they had a milder form of DLD: mainly phonologic programming deficit syndrome. The other three children had different imaging findings. CONCLUSIONS: Developmental language disorder can be associated with polymicrogyria and the clinical manifestation varies according to the extension of cortical abnormality. A subtle form of posterior parietal polymicrogyria presenting as developmental language disorder is a mild form of perisylvian syndrome.

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Adolescent Brain Diseases Cerebral Cortex Child Child, Preschool Female Humans Language Development Disorders Male Phonetics Prospective Studies Semantics Journal Article Research Support, Non-U.S. Gov't

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M M Guerreiro, S R V Hage, C A Guimarães, D V Abramides, W Fernandes, P S Pacheco, A M S G Piovesana, M A Montenegro, F Cendes. 2002-07-23. Developmental language disorder associated with polymicrogyria.. https://doi.org/10.1212/wnl.59.2.245

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