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The renal type IIa Na/Pi cotransporter: structure-function relationships.

Heini Murer·Katja Köhler·Georg Lambert·Gert Stange·Jürg Biber·Ian Forster
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Abstract

The type IIa Na/Pi cotransporter mediates proximal tubular brush-border membrane secondary active phosphate (Pi) flux. It is rate limiting in tubular Pi reabsorption and, thus, a final target in many physiological and pathophysiological situations of altered renal Pi handling. In the present short review, we will briefly summarize our current knowledge about the transport mechanism (cycle) as well as particular regions of the transporter protein ("molecular domains") that potentially determine transport characteristics.

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Amino Acid SequenceAnimalsBiological Transport, ActiveCysteineDisulfidesHumansHydrogen-Ion ConcentrationKidney Tubules, ProximalMicrovilliModels, StructuralMutagenesis, Site-DirectedPhosphatesProtein Structure, TertiaryRecombinant Fusion ProteinsSequence Homology, Amino AcidSodiumSodium-Phosphate Cotransporter ProteinsSodium-Phosphate Cotransporter Proteins, Type IIaStructure-Activity RelationshipSymportersJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Heini Murer, Katja Köhler, Georg Lambert, Gert Stange, Jürg Biber, Ian Forster. 2002. The renal type IIa Na/Pi cotransporter: structure-function relationships.. https://doi.org/10.1385/cbb%3A36%3A2-3%3A215

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