Memory CD8(+) T cells undergo peripheral tolerance.

Huub T C Kreuwel; Sandra Aung; Cheryl Silao; Linda A Sherman

doi:10.1016/s1074-7613(02)00337-0

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Memory CD8(+) T cells undergo peripheral tolerance.

Huub T C Kreuwel·Sandra Aung·Cheryl Silao·Linda A Sherman

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Abstract

Memory T cells differ from naive T cells in that they respond more rapidly and in greater numbers. In addition, memory T cells are generally believed to be less susceptible to tolerance induction than naive T cells. In this study, we show that this is not the case. Using two different methods of tolerance induction, peptide-induced tolerance and crosstolerance, we present evidence that memory CD8(+) T cells are as susceptible to tolerance as naive cells. These results have a direct impact on manipulating T cell responses to self-antigens in order to improve immunotherapy of cancer and autoimmune diseases.

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Animals Animals, Newborn Autoantigens Cell Line Clone Cells Diabetes Mellitus Genes, T-Cell Receptor Hemagglutinins Immune Tolerance Immunologic Memory Lymph Nodes Mice Mice, Inbred BALB C Pancreas Peptides T-Lymphocytes, Cytotoxic Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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Huub T C Kreuwel, Sandra Aung, Cheryl Silao, Linda A Sherman. 2002. Memory CD8(+) T cells undergo peripheral tolerance.. https://doi.org/10.1016/s1074-7613(02)00337-0

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