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Telomerase beyond telomeres.

María A Blasco
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Abstract

The role of telomerase in actively proliferating cells is assumed to be restricted to maintaining of telomeres above a minimum-length threshold, thereby preventing telomere exhaustion and chromosomal instability. However, forced telomerase expression in cells and mice with normal-length telomeres has shown that telomerase promotes growth and survival in a manner that is uncoupled from net telomere lengthening. These findings imply that telomerase might have a fundamental role in tumour growth and survival, even at stages when telomeres are sufficiently long.

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AnimalsCell DivisionHumansMiceNeoplasmsTelomeraseTelomereResearch Support, Non-U.S. Gov'tReviewJournal Article

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María A Blasco. 2002. Telomerase beyond telomeres.. https://doi.org/10.1038/nrc862

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