Combinatorial protein design.

Jeffery G Saven

doi:10.1016/s0959-440x(02)00347-0

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Combinatorial protein design.

Jeffery G Saven

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Abstract

Combinatorial protein libraries permit the examination of a wide range of sequences. Such methods are being used for denovo design and to investigate the determinants of protein folding. The exponentially large number of possible sequences, however, necessitates restrictions on the diversity of sequences in a combinatorial library. Recently, progress has been made in developing theoretical tools to bias and characterize the ensemble of sequences that fold into a given structure - tools that can be applied to the design and interpretation of combinatorial experiments.

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Amino Acids Combinatorial Chemistry Techniques Database Management Systems Databases, Protein Information Storage and Retrieval Peptide Library Protein Conformation Protein Engineering Protein Folding Proteins Sequence Analysis, Protein Sequence Homology Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Review

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Jeffery G Saven. 2002. Combinatorial protein design.. https://doi.org/10.1016/s0959-440x(02)00347-0

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