Exact genetic linkage computations for general pedigrees.

M Fishelson; D Geiger

doi:10.1093/bioinformatics/18.suppl_1.s189

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Exact genetic linkage computations for general pedigrees.

M Fishelson·D Geiger

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Abstract

MOTIVATION: Genetic linkage analysis is a useful statistical tool for mapping disease genes and for associating functionality of genes with their location on the chromosome. There is a need for a program that computes multipoint likelihood on general pedigrees with many markers that also deals with two-locus disease models. RESULTS: In this paper we present algorithms for performing exact multipoint likelihood calculations on general pedigrees with a large number of highly polymorphic markers, taking into account a variety of disease models. We have implemented these algorithms in a new computer program called SUPERLINK which outperforms leading linkage software with regards to functionality, speed, memory requirements and extensibility.

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Algorithms Bayes Theorem Chromosome Mapping Coronary Artery Disease Gene Expression Profiling Genetic Linkage Genetic Predisposition to Disease Genetic Testing Humans Models, Genetic Models, Statistical Pedigree Phylogeny Software Comparative Study Evaluation Study Journal Article Research Support, Non-U.S. Gov't Validation Study

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M Fishelson, D Geiger. 2002. Exact genetic linkage computations for general pedigrees.. https://doi.org/10.1093/bioinformatics%2F18.suppl_1.s189

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