Optimizing parameters for terminating cortical afterdischarges with pulse stimulation.

Gholam K Motamedi; Ronald P Lesser; Diana L Miglioretti; Yuko Mizuno-Matsumoto; Barry Gordon; William R S Webber; Darryl C Jackson; Jehuda P Sepkuty; Nathan E Crone

doi:10.1046/j.1528-1157.2002.24901.x

PubMed · 12181002

Optimizing parameters for terminating cortical afterdischarges with pulse stimulation.

Gholam K Motamedi·Ronald P Lesser·Diana L Miglioretti·Yuko Mizuno-Matsumoto·Barry Gordon·William R S Webber·Darryl C Jackson·Jehuda P Sepkuty·Nathan E Crone

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Abstract

PURPOSE: We previously reported that brief pulses of electrical stimulation (BPSs) can terminate afterdischarges (ADs) during cortical stimulation. We investigated conditions under which BPS is more likely to suppress ADs. METHODS: We analyzed parameters altering BPS effectiveness on 200 ADs in seven patients with implanted subdural electrodes. RESULTS: The odds of BPSs stopping ADs was 8.6 times greater at primary sites (directly stimulated electrodes) than at secondary sites (adjacent electrodes) (p = 0.016). BPS applied within 4.5 s after onset of AD had 2 times greater odds of stopping ADs (p = 0.014). BPS applied when AD voltage was negative was 1.9 times more likely to stop ADs (p = 0.012). ADs with rhythmic pattern responded best (p < 0.0001). BPS stopped 100% of ADs not starting immediately after localization stimulus (LS) versus 29% of those starting immediately (p < 0.0001). CONCLUSIONS: BPS is more likely to terminate ADs at primary electrodes, if given early, if applied to the negative peak of the AD waveform, if AD has a rhythmic pattern, and if AD did not start immediately after LS.

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Adolescent Adult Anticonvulsants Cerebral Cortex Child Child, Preschool Electric Stimulation Therapy Epilepsies, Partial Female Humans Male Middle Aged Periodicity Reaction Time Treatment Outcome Journal Article

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Gholam K Motamedi, Ronald P Lesser, Diana L Miglioretti, Yuko Mizuno-Matsumoto, Barry Gordon, William R S Webber, Darryl C Jackson, Jehuda P Sepkuty, Nathan E Crone. 2002. Optimizing parameters for terminating cortical afterdischarges with pulse stimulation.. https://doi.org/10.1046/j.1528-1157.2002.24901.x

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