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PubMed · 12185332

p63 expression in normal, hyperplastic and malignant breast tissues.

Xiaojuan Wang·Ichiro Mori·Weihua Tang·Misa Nakamura·Yasushi Nakamura·Misako Sato·Takeo Sakurai·Kennichi Kakudo
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Abstract

BACKGROUND: p63 is a homologue of the p53 tumor suppressor gene and its protein is selectively expressed in the basal cells of a variety of epithelial tissues. It has recently been confirmed that p63 is expressed in the basal cells of normal prostate glands but not in prostatic carcinomas. Whether expression of p63 in breast correlates with tumor progression is the focus of this study. METHODS: Forty cases, which all contained normal breast tissue, ductal hyperplasia, ductal carcinoma in situ and invasive ductal carcinoma in the same patient were included in this investigation using an indirect immunohistochemical method and double staining. RESULTS: p63 was exclusively expressed in the myoepithelial cells of normal breast, partially expressed in ductal hyperplasia, rarely expressed in carcinoma in situ and not expressed in invasive carcinomas. CONCLUSION: The results suggest an association between loss of p63 expression and progression of breast ductal carcinoma. p63 immunostaining might be of assistance for distinguishing invasive ductal carcinoma from ductal carcinoma in situ or rare questionable ductal hyperplastic lesions, leading to correct therapy clinically.

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Biopsy, NeedleBreast DiseasesBreast NeoplasmsCarcinoma in SituCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCulture TechniquesDiagnosis, DifferentialFemaleGene Expression RegulationGenes, Tumor SuppressorGenes, p53Genetic Predisposition to DiseaseHumansHyperplasiaImmunohistochemistryProbabilityReference ValuesSensitivity and SpecificityComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Xiaojuan Wang, Ichiro Mori, Weihua Tang, Misa Nakamura, Yasushi Nakamura, Misako Sato, Takeo Sakurai, Kennichi Kakudo. 2002. p63 expression in normal, hyperplastic and malignant breast tissues.. https://doi.org/10.1007/bf02967592

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Targeting difficult accessible breast lesions: MRI-guided needle localization using a freehand technique in a 3.0 T closed bore magnet.

PURPOSE: To report the accuracy of magnetic resonance imaging (MRI)-guided needle localization for diagnosis of MRI detected suspicious breast lesions located in difficult accessible regions of the breast, using the freehand method in a 3.0 T closed bore magnet. MATERIALS AND METHODS: In five patients with five MRI-only breast lesions underwent MRI-guided needle localization for histopathologic evaluation of the lesions. All interventional procedures were performed in a 3.0 T MRI system with the patient in prone position and by using a dedicated phased array breast coil. MRI-guided needle localizations were performed by using a freehand technique. In our study, the high-resolution scan allowed preprocedural localization of all lesions without use of contrast enhancement. In all cases contrast-enhanced MRI was performed after insertion of the wire to confirm the tip of the wire in direct contact with the enhancing lesion. RESULTS: Needle localizations were performed in five patients. Histopathologic evaluation of tissue after surgery excision biopsy revealed one lymph node, three invasive ductal carcinoma and one ductal carcinoma in situ. Lesion size varied from 6 to 30 mm. Mean duration time was 25 min. No complications occurred during the intervention method. In the patient with the benign lesion control MRI of the breast after 6 months confirmed lesion removal. CONCLUSIONS: MRI-guided needle localization by using a freehand technique in a 3.0 T closed bore magnet is a safe and accurate method for diagnosis of difficult accessible breast lesions only visible on MRI.

Biopsy, Needle↗