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PubMed · 12186188

The hepatic immune system.

Mary Jo Wick·Frank Leithäuser·Jörg Reimann
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Abstract

The liver regulates T-cell homeostasis, induces T-cell tolerance, and supports intrahepatic T-cell responses against hepatotropic pathogens. Many data from clinical and preclinical systems provide supportive evidence for these diverse roles of the liver in modulating peripheral (systemic, mucosal, and intrahepatic) T-cell immunity. Little information is available on the cellular and molecular mechanisms that mediate the dual role of the liver in tolerizing T-cell responses and in supporting intrahepatic priming of T-cell responses. Understanding these immunoregulatory effects in the liver may offer insight into clinically relevant immunopathologies of this organ.

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Antigen PresentationDendritic CellsHepatitisHumansLiverSelf ToleranceT-LymphocytesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Mary Jo Wick, Frank Leithäuser, Jörg Reimann. 2002. The hepatic immune system.. https://pubmed.ncbi.nlm.nih.gov/12186188/

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