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Differentiated thyroid carcinoma: a polygenic disease.

T P Links·K M van Tol·G J Meerman·E G de Vries
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Abstract

Differentiated thyroid cancer is a rare disease and until recently was considered to be sporadic. However, increasing evidence has been found for a genetic basis of this disease. In approximately 5% of patients the differentiated thyroid cancer is dominantly inherited. Several families with different syndromes, of which differentiated thyroid cancer is a feature, have already been described. However, until now, single genes explain only a minority of cases. We hypothesize that differentiated thyroid cancer is a polygenic disease. Data from epidemiologic studies, about occult and multifocal carcinomas and the different response to specific risk factors contribute to this hypothesis.

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T P Links, K M van Tol, G J Meerman, E G de Vries. 2001. Differentiated thyroid carcinoma: a polygenic disease.. https://doi.org/10.1089/10507250152740975

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