PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 12195809

Steroids: reactions and partial synthesis.

J R Hanson
View original source ↗Export metadata ↓

Abstract

The article reviews the progress in the chemistry of the steroids that was published between January and December, 2000. The reactions and partial syntheses of estrogens, androgens, pregnanes, cholic acid derivatives, cholestanes and vitamin D analogues are covered. There are 169 references.

Explore related subjects

AlcoholsAlkenesAndrostanesCholestanesCholic AcidsCrystallography, X-RayEpoxy CompoundsEstranesMagnetic Resonance SpectroscopyMolecular StructurePregnanesSteroidsStructure-Activity RelationshipVitamin DJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J R Hanson. 2002. Steroids: reactions and partial synthesis.. https://doi.org/10.1039/b109034h

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Intermolecular electrophilic O-amination of alcohols.

We report the first examples of an intermolecular electrophilic O-amination of aliphatic alcohols. Thus, the new reagents, fluorenone oxime tosylate, 5a, or mesylate, 5b, permit O-amination of diverse alcohols in the presence of NaH under mild conditions. By following the formation of the resulting oxime ethers, 6, the reaction was shown to be sensitive to steric effects in the alcohol. Furthermore, the presence of an aromatic ring or of a double bond in the alcohol molecule (benzyl, allyl) was found to increase the reaction rate.

Alcohols↗
PubMed2007

Asymmetric amplification in catalysis by trans-1,2-diaminocyclohexane bistriflamide.

A strong asymmetric amplification is observed in the addition of diethylzinc on aromatic aldehydes in the presence of the bistriflamide of trans-1,2-diaminocyclohexane 3a. The asymmetric amplification originates from the insolubility of the catalyst precursor 3a of low enantiomeric excess (ee), with a concomitant large increase of ee for the minor soluble part of 3a. Controlled mono-N-acetylation of 3a (20% ee) at -78 degrees C allowed isolation of 4 possessing 90% ee. [reaction: see text].

Alcohols↗
PubMed2007

Anionic four-electron donor-based palladacycles as catalysts for addition reactions of arylboronic acids with alpha,beta-unsaturated ketones, aldehydes, and alpha-ketoesters.

Anionic four-electron donor-based palladacycle-catalyzed 1,4-additions of arylboronic acids with alpha,beta-unsaturated ketones and 1,2-additions of arylboronic acids with aldehydes and alpha-ketoesters are described. Our study demonstrated that palladacycles were highly efficient, practical catalysts for these addition reactions. The work described here not only opened a new paradigm for the application of palladacycles, but may also pave the road for other metalacycles as practically useful catalysts for such addition reactions including asymmetric ones. [reaction: see text].

Alcohols↗