Solid-phase compound library synthesis in drug design and development.

Paul J Edwards; Andrew I Morrell

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PubMed · 12197317

Solid-phase compound library synthesis in drug design and development.

Paul J Edwards·Andrew I Morrell

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Abstract

This article is a subjective review of the literature between December 2000 and January 2002 related to the solid-phase synthesis of compound libraries for drug discovery and development. Examples of libraries yielding active compounds across a range of biological targets are presented, together with synthetic details where this is deemed of sufficient note. Background to the biological target and any structure-activity relationship, which can be discerned within members of a library series, is also discussed. A brief overview of new developments in solid-phase technology that is likely to impact upon drug discovery is also included.

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Animals Combinatorial Chemistry Techniques Drug Design Humans Technology, Pharmaceutical Journal Article Review

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Paul J Edwards, Andrew I Morrell. 2002. Solid-phase compound library synthesis in drug design and development.. https://pubmed.ncbi.nlm.nih.gov/12197317/

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