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PubMed · 12200155

Intramembrane proteolysis controls diverse signalling pathways throughout evolution.

Sinisa Urban·Matthew Freeman
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Abstract

Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.

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Active Transport, Cell NucleusAnimalsCell CommunicationCell NucleusCysteine EndopeptidasesCytoplasmEndopeptidasesEvolution, MolecularHumansIntracellular MembranesMultienzyme ComplexesProteasome Endopeptidase ComplexSignal TransductionTranscription FactorsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Sinisa Urban, Matthew Freeman. 2002. Intramembrane proteolysis controls diverse signalling pathways throughout evolution.. https://doi.org/10.1016/s0959-437x(02)00334-9

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