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PubMed · 12209132

WASp in immune-system organization and function.

Adrian J Thrasher
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Abstract

The regulation of many immunological events depends on systems that mediate dynamic actin reorganization in response to signals from the cell membrane. The Wiskott-Aldrich syndrome protein (WASp) is the founding member of a family of proteins that have emerged as crucial effectors of Rho GTPases and activators of the cytoskeletal-organizing complex Arp2/3. Now, WASp has been shown to be intimately involved in many pathways that influence the function of the immune system. Disturbances in these systems result in the complex immunodysregulation of Wiskott-Aldrich syndrome.

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Actin-Related Protein 2Actin-Related Protein 3ActinsAnimalsBlood CellsCell MembraneCytoskeletal ProteinsHumansLymphocytesMicrofilament ProteinsNerve Tissue ProteinsPhagocytosisProteinsSignal TransductionWiskott-Aldrich SyndromeWiskott-Aldrich Syndrome ProteinWiskott-Aldrich Syndrome Protein FamilyWiskott-Aldrich Syndrome Protein, Neuronalrho GTP-Binding ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Adrian J Thrasher. 2002. WASp in immune-system organization and function.. https://doi.org/10.1038/nri884

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