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Chromatin modification and epigenetic reprogramming in mammalian development.

En Li
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Abstract

The developmental programme of embryogenesis is controlled by both genetic and epigenetic mechanisms. An emerging theme from recent studies is that the regulation of higher-order chromatin structures by DNA methylation and histone modification is crucial for genome reprogramming during early embryogenesis and gametogenesis, and for tissue-specific gene expression and global gene silencing. Disruptions to chromatin modification can lead to the dysregulation of developmental processes, such as X-chromosome inactivation and genomic imprinting, and to various diseases. Understanding the process of epigenetic reprogramming in development is important for studies of cloning and the clinical application of stem-cell therapy.

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AnimalsChromatinDNA MethylationEctodermEmbryonic and Fetal DevelopmentGerm CellsHumansMammalsModels, GeneticTrophoblastsX ChromosomeJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

En Li. 2002. Chromatin modification and epigenetic reprogramming in mammalian development.. https://doi.org/10.1038/nrg887

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