ONO-6818 Cortech/Ono.

Alexandre Trifilieff

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PubMed · 12211408

ONO-6818 Cortech/Ono.

Alexandre Trifilieff

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Abstract

ONO-6818 (CP-955) is the lead compound in a series of orally bioavailable neutrophil elastase inhibitors licensed from Cortech and under investigation by Ono for the potential treatment of inflammatory conditions, such as rheumatoid arthritis, inflammatory bowel disease and chronic obstructive pulmonary disease (COPD) [174095]. ONO-6818 was in phase I studies for COPD in Japan as of December 1999 [366431]. Phase I trials for this indication in Japan and the US were ongoing in September 2001 [368565], [422782], [446138]. As of June 2002, however, a number of unconfirmed reports stated that the compound had moved into phase II trials in Japan and was in preparation for phase II trials in the US [456596], [456597].

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Animals Anti-Inflammatory Agents Clinical Trials, Phase I as Topic Enzyme Inhibitors Humans Leukocyte Elastase Oxadiazoles Pyrimidinones Journal Article Review

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Alexandre Trifilieff. 2002. ONO-6818 Cortech/Ono.. https://pubmed.ncbi.nlm.nih.gov/12211408/

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