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Transcript elongation on a nucleoprotein template.

Grant A Hartzog·Jennifer L Speer·Derek L Lindstrom
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Abstract

Chromatin forms a general, repeating barrier to elongation of transcripts by eukaryotic RNA polymerases. Recent studies of nucleosome structure and histone modifications reveal a set of likely mechanisms for control of elongation through chromatin. Genetic and biochemical studies of transcription have identified a set of accessory factors for transcript elongation by RNA polymerase II (Pol II) that appear to function in the context of chromatin. The C-terminal repeated domain (CTD) of Pol II may also play a role in regulating elongation through chromatin.

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ChromatinGene Expression RegulationNucleoproteinsNucleosomesPeptide Chain Elongation, TranslationalPeptide Chain Initiation, TranslationalRNA Polymerase IISaccharomyces cerevisiaeTemplates, GeneticTranscription Factors, GeneralTranscription, GeneticTranscriptional Elongation FactorsJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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Grant A Hartzog, Jennifer L Speer, Derek L Lindstrom. 2002-09-13. Transcript elongation on a nucleoprotein template.. https://doi.org/10.1016/s0167-4781(02)00458-x

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