Cell surface immunoglobulin receptors in B cell development.

Kelly A Pike; Michael J H Ratcliffe

doi:10.1016/s1044-5323(02)00068-4

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Cell surface immunoglobulin receptors in B cell development.

Kelly A Pike·Michael J H Ratcliffe

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Abstract

Expression of surface immunoglobulin (sIg) related receptors has been conserved in phylogenetically distinct species as a critical checkpoint in B cell development. The sIg receptor comprises extracellular IgM heavy and light chains, with the potential for ligand binding, complexed to the Igalpha/Igbeta heterodimer that is responsible for signal transduction through sIg. Experimental systems, from both avian and murine models of B cell development, have been designed to identify the function of individual receptor components in B cell development. In this review, we assess the regulatory functions of different components of the sIg receptor complex during early development in experimental systems from evolutionarily distinct species.

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Animals B-Lymphocytes Cell Differentiation Dimerization Gene Expression Regulation, Developmental Gene Rearrangement, B-Lymphocyte Humans Immunoglobulin M Membrane Glycoproteins Pre-B Cell Receptors Receptors, Antigen, B-Cell Signal Transduction Species Specificity Comparative Study Journal Article Review

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Kelly A Pike, Michael J H Ratcliffe. 2002. Cell surface immunoglobulin receptors in B cell development.. https://doi.org/10.1016/s1044-5323(02)00068-4

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