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PubMed · 12226851

Solid phases of tenoxicam.

Rodrigo G Cantera·María G Leza·Carmen M Bachiller
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Abstract

In this report we describe the preparation and characterization of four polymorphic forms of tenoxicam; they are, three 1:1 stoichiometric solvates with acetonitrile, dioxane, and N,N-dimethylformamide, and an amorphous phase obtained by recrystallization in various solvents. Polymorph IV and solvates with dioxane and N,N-dimethylformamide are reported for the first time in this paper. In addition, three solvates were crystallized in acetone, ethyl acetate, and isopropyl alcohol. These solid forms were characterized by X-ray powder diffraction, differential scanning calorimetry, infrared spectroscopy, thermogravimetry, optical microscopy, and elemental analysis. Solid-state properties, intrinsic dissolution rate, and dissolution kinetics from formulated tablets are also provided.

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1-Butanol2-PropanolAcetamidesAcetatesAcetoneAcetonitrilesBenzeneCalorimetry, Differential ScanningChemical PhenomenaChemistry, PhysicalChloroformCrystallography, X-RayDimethylformamideDioxanesHydrogen-Ion ConcentrationKineticsPiroxicamSolubilitySolventsSpectrophotometry, InfraredSpectrophotometry, UltravioletJournal ArticleResearch Support, Non-U.S. Gov't

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Rodrigo G Cantera, María G Leza, Carmen M Bachiller. 2002. Solid phases of tenoxicam.. https://doi.org/10.1002/jps.10207

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