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PubMed · 12231347

Desmosomal cadherins.

David R Garrod·Anita J Merritt·Zhuxiang Nie
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Abstract

New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mice suggests that they may function directly or indirectly in regulating epidermal differentiation. Protein kinase C signalling and tyrosine phosphorylation appear to regulate desmosomal adhesion. There are new insights into the role of desmosomal cadherins in autoimmune, infectious and genetic disease.

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AnimalsCadherinsCell AdhesionDesmosomesEpidermisGenotypeHumansMiceMice, KnockoutModels, BiologicalPhenotypeProtein BindingJournal ArticleResearch Support, Non-U.S. Gov'tReview

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David R Garrod, Anita J Merritt, Zhuxiang Nie. 2002. Desmosomal cadherins.. https://doi.org/10.1016/s0955-0674(02)00366-6

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