Cell interactions with three-dimensional matrices.

Edna Cukierman; Roumen Pankov; Kenneth M Yamada

doi:10.1016/s0955-0674(02)00364-2

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Cell interactions with three-dimensional matrices.

Edna Cukierman·Roumen Pankov·Kenneth M Yamada

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Abstract

Signaling and other cellular functions differ in three-dimensional compared with two-dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like adhesions with distinct biological activities. In this review, we examine recent advances in studies of interactions of fibroblasts with collagen gels and fibronectin-containing matrices that mimic in vivo three-dimensional microenvironments. These three-dimensional systems are illuminating mechanisms of cell-matrix interactions in living organisms.

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Animals Cell Adhesion Collagen Fibroblasts Fibronectins Humans Microscopy, Confocal Models, Biological Protein Binding Signal Transduction Journal Article Review

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Edna Cukierman, Roumen Pankov, Kenneth M Yamada. 2002. Cell interactions with three-dimensional matrices.. https://doi.org/10.1016/s0955-0674(02)00364-2

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